Cognitive performance in juvenile myoclonic epilepsy patients with specific endophenotypes
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چکیده
منابع مشابه
Cognitive performance in juvenile myoclonic epilepsy patients with specific endophenotypes
PURPOSE Juvenile myoclonic epilepsy (JME) is a heterogeneous syndrome in which seizures can be precipitated not only by non-specific factors, such as sleep deprivation and stress, but also by specific stimuli, such as photic stimuli, eye-closure, praxis, and language. The presence of these reflex traits may indicate the hyperexcitability of different cortical areas, which may be reflected in pa...
متن کاملPrognosis of juvenile myoclonic epilepsy is related to endophenotypes
PURPOSE To investigate if phenotypic variations have prognostic implications in juvenile myoclonic epilepsy (JME). METHODS Sixty-five consecutive JME patients had video-EEG recording and were followed for at least three years. Reflex traits were defined as seizures and/or EEG discharges induction by eye-closure, photic stimulation, language, praxis or calculation. Patients had psychiatric eva...
متن کاملTopiramate in patients with juvenile myoclonic epilepsy.
BACKGROUND Topiramate is a broad-spectrum agent effective against primarily generalized tonic-clonic seizures (PGTCS) as well as partial-onset seizures. Juvenile myoclonic epilepsy is one of the most common idiopathic generalized epilepsies, with most patients experiencing PGTCS. OBJECTIVE To evaluate topiramate as add-on therapy in patients with juvenile myoclonic epilepsy. DESIGN Post-hoc...
متن کاملCognitive Impairment in Juvenile Myoclonic Epilepsy
BACKGROUND AND PURPOSE Cognitive impairments are frequent consequences of epilepsy, with intellectual ability reportedly being lower in patients with idiopathic generalized epilepsies than in the general population. However, neuropsychological investigations have been rarely performed in patients with juvenile myoclonic epilepsy (JME). We aimed to quantify the cognitive function in JME patients...
متن کاملTreatment of myoclonic seizures in patients with juvenile myoclonic epilepsy
Drug treatment of Juvenile myoclonic epilepsy (JME) is mainly based on clinical experience and prospective and retrospective studies, with little evidence from randomized clinical trials. There are no head-to-head comparisons between old and new antiepileptic drugs (AEDs) and no drugs licensed specifically for JME. Valproate is unquestionably the drug of the first choice in men with JME. In wom...
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ژورنال
عنوان ژورنال: Seizure
سال: 2016
ISSN: 1059-1311
DOI: 10.1016/j.seizure.2016.06.002